Better Chemistry Through Lab-on-a-Chip Microreactors

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报告题目：Better Chemistry Through Lab-on-a-Chip Microreactors

报告人：Prof. Dong-Pyo Kim，
　　　　Center of Applied Microfluidic Chemistry, Chungnam National University, Daejeon 305-764, Korea

报告时间：5月24日（周二），下午2：00

报告地点：化学楼演讲厅

邀请人：车顺爱 教授（化学化工学院）

Better Chemistry Through Lab-on-a-Chip Microreactors

Dong-Pyo Kim
Center of Applied Microfluidic Chemistry, Chungnam National University, Daejeon 305-764, Korea, E-mail: dpkim@cnu.ac.kr

Microfluidic synthesis has received much attention because of the advantages it offers such as high surface area to volume ratio at the microscale, fast mass and heat transfer, and short diffusion distance. And, the alternative advantages of microreactors such as increased safety, decreased inputs and waste, the potential for catalyst recycling and the opportunity for low-volume optimization, make them ideal for doing more environmentally benign chemistry. Moreover, in microreactors the better thermal and mixing control over chemical processes leads to higher reproducibility and better efficiency than traditional batch process. Microreactors with continuous flow are also desired for multiple transformations of fine chemicals.
This presentation will cover Lab-on-a-chip microchemical systems fabricated from PDMS, polyimide (PI) film and functional inorganic polymers by various lithographic techniques, which have been used to look for microreactor applications in the areas of organic, polymer and inorganic syntheses. At first, Lab-on-a-chip microreactors with high resistance against organic solvents were fabricated with flexible PI film and fluoropolymer using simple techniques for various organic reactions.(Fig. 1) Secondly, built-in microreactors embedded with the bead packed structure, macroporous structure and grown nanowires in the microchannel were used for heterogeneous catalytic reactions, mixer applications.(Fig. 2) As summarized in Fig. 3, various droplet-based microreactors composed of lab on a chip type of drop generator and capillary tube were used for synthesis of Janus microspheres with dumbbell-shaped morphology, a consecutive step-wise process for well-defined diblock copolymers. And ionic liquid assisted droplet microfluidic system was devised for rapid synthesis of unaccommodating nanoporous Zeolite ZSM-5 nanoparticles under mild condition. Additionally, bio-applications such as cell-free protein synthesis and electroporation of microalgae could be combined with microfluidic droplets. At the last part, PDMS microfluidics were still useful for carefully designed synthetic chemistry such as efficient gas-liquid reactions in dual-channel, continuous recovery and recirculation of catalyst-immobilized magnetic particles.

Finally, it is truly believed that the burgeoning field of microreactor technology can have a significant impact for industrial chemists as well as for the bench chemist designing new methodologies.



Fig. 1. Various solvent Resistant Microreactors Fabricated from Various Materials.



Fig. 2. Various Built-in Microreactors with Embedded Structures in Microchannels.



Fig. 3. Various Droplet-based Microreactors Composed of Lab-on-a-Chip as a Drop Generator and Capillary Tube.

Autobiography

Prof. Dong-Pyo Kim received Ph.D. in Chemistry (Temple Univ.) at 1991 and shifted to Materials Sci. & Eng (UIUC) as a post-doctoral position. In 1993, he joined as a senior researcher at Korea Research Institute of Chemical Technology. Since 1995, he has worked at Department of applied chemistry, Chungnam National University in Korea. He began his career at the area of materials chemistry including inorganic polymers. Since 2004 he devotes to lab-on-a-chip microreactors under National Research Lab grant, and currently as a head of Center of Applied Microfluidic Chemistry under Creative Research Initiatives program for 9 yrs.